ACLF Masterclass: Concepts, Controversies, and Clinical Care: LDDC at the Forefront of Advanced Liver Care

Dr. Pukar Thapa Presents at Gastro Core 2.0, Bhairahawa

Liver and Digestive Disease Center (LDDC) is proud to highlight the academic contribution of Dr. Pukar Thapa, who presented at the Gastro Core 2.0 Conference 2026, held at Tiger Palace Resort, Bhairahawa.

His presentation focused on:

“Overview and Management of Acute-on-Chronic Liver Failure (ACLF)”

The session addressed one of the most complex and high-mortality conditions in hepatology, emphasizing early recognition, risk stratification, and evidence-based management strategies.

Understanding ACLF: A Critical Hepatology Challenge

Acute-on-Chronic Liver Failure (ACLF) is a rapidly progressive clinical syndrome occurring in patients with pre-existing chronic liver disease, characterized by acute deterioration of liver function and multi-organ failure.

It is associated with high short-term mortality and requires urgent, structured clinical intervention.

Dr. Thapa’s presentation highlighted the importance of:

• Early identification of ACLF triggers
• Systematic assessment of disease severity
• Multi-organ support in critical care settings
• Timely referral and escalation of care
• Individualized treatment planning based on clinical staging

Evidence-Based Management Approach

The discussion emphasized a stepwise clinical approach:

• Stabilization of the patient in acute decompensation
• Identification and treatment of precipitating factors (infections, alcohol, drug toxicity, etc.)
• Supportive management of organ failures
• Evaluation for advanced therapies including transplant referral where applicable

The presentation reinforced that ACLF management requires rapid decision-making, multidisciplinary care, and close monitoring, especially in resource-limited settings.

Advancing Hepatology Practice in Nepal

By contributing to national academic platforms like Gastro Core 2.0, Dr. Thapa continues to support the advancement of hepatology practice in Nepal.

Such academic engagements reflect LDDC’s broader commitment to:

• Clinical excellence in liver disease management
• Continuous medical education
• Evidence-based practice
• Strengthening critical care hepatology services

Conclusion

ACLF remains one of the most challenging conditions in modern hepatology. Through structured clinical frameworks and academic engagement, LDDC aims to improve early recognition and outcomes for patients with advanced liver disease in Nepal.